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Discover Evening Pure Stimulus — the first rosacea-safe retinoid, suitable for acclimatization to tazarotene.

Learn more below or click here.

Evening Pure Stimulus Retinaldehyde

Soothing individual-use retinaldehyde capsules with a new hermetic, easy to open preservative-free capsule design for easily-irritated skin in need of maximum anti-aging restoration.

Superior to retinol, retinyl acetate and retinyl palmitate.

Allows rosacea patients to benefit from the proven benefits of topical retinoids (forms of Vitamin A) without jeopardising progress in restoring skin barrier function and capillary stability.

Effective in acclimatising skin to tazarotene.

  • evening use
  • rapidly absorbed ultra-light dry oil serum (no residue)
  • complete absorption prevents irritation from Vitamin A at the skin's surface
  • silicone-free
  • suitable for all skin types
  • preservative-free
  • new hermetic capsule design for 2017

Innovative Ingredients

Ultra-Light Olive Squalane + Glycine Soya (Soybean) Sterols + Lysolecithin — provide a sheer serum without potential irritancy or discomfort of silicones; does not interfere with absorption of subsequently applied products or medications (in contrast with the occlusive nature of silicones); isolated soybean sterols help progressively reduce discoloration.

Retinaldehyde — superior skin interaction and absorption compared to other forms of Vitamin A; negligible prospect of adverse effects when used as directed.

Ubiquinone — also known as Co-Enzyme Q10, contributes to safely re-energising skin;

Silymarin Ethyl Ester — provides the antioxidant and anti-inflammatory benefits of silymarin to the oil-soluble components of cells, helping enhance this aspect of other treatments such as Intensive Night Nurturing Complex.

Linoleic Acid + Oleic Acid + Ceramides — low concentration allows thorough absorption of retinaldehyde while compensating for increased exfoliation (and associated skin barrier function disruption associated with topical Vitamin A use) due to the increased rate of cellular renewal.

Phytosterols — extremely light and well-absorbed extracts of plant oils, work synergistically with ceramides and the pure squalane which forms the basis of the serum; benefits similar to cholesterol without hindering absorption.


The latest hermetic capsules do not require the addition of preservatives, further reducing the likelihood of irritation and maintain the full activity of retinaldehyde up to the point of application.


Evening use only.

This product is rapidly deactivated by ulraviolet light, even once absorbed (not for daytime use).

Please see the frequency of use guide below.

In the evening, cleanse skin with Pre-Cleansing Emulsifier and Anti-Inflammatory Foaming Cleanser, Oil-Free Purifying Gel Cleanser or Hydrating De-Sensitising Cleansing Emulsion. Spray with Desensitising Epicatechin Serum-Mist, Hydrating Mist or Purifying Mist.

Apply to dry skin.

Cut or twist off the top of the capsule.

Squeeze gently and apply the contents of one capsule to the face and neck, section-by-section.

Massage gently until completely absorbed.

Follow with Anti-Inflammatory Clearing Serum (if used) and/or Intensive Night Nurturing Complex, Treatment Fluid or Treatment Cream.

This evening-use product must be combined with daytime use of sunscreen to be as effective as possible. Unprotected UV exposure will reverse Vitamin A's benefits.

Frequency of Use

If your skin is extremely sensitive, progressively increase use to reduce any likelihood of irritation.

  • 1st week — one capsule every three nights.
  • 2nd week — one capsule every other night.
  • 3rd week — one capsule nightly.
  • After 2 months optionally apply up to 3 capsules nightly to improve results.

Use Around Eyes

Use around the eyes is desirable, with caution.

Apply around the eyes once every three days at the commencement of use.

Increase frequency of application every 1-2 weeks as tolerated.

Wear sunglasses in preference to applying sunscreen around the most immediate eye area.


After 4-8 months you may be able to make a transition to tazarotene, the most potent form of topical Vitamin A.

Rosacea Skin Care Resolutions

Our rosacea skin care resolutions for 2014 recognize that time is of essence.

Making and breaking new year's resolutions can be a humourless cliché, nevertheless the new year is as good a time as any to start, correct or refine the treatment of your rosacea.

The following rosacea skin care resolutions are realistic enough for year-long use and therefore don't have to become exercises in futility.

Treat Now, Not Later

Rosacea is a chronic disease. When left untreated it typically worsens and becomes more difficult to treat.

Resolve to address and manage symptoms as they occur and not in a piecemeal manner.

Recognize that time is not unlimited when it comes to getting things right with your skin.

Take Skin Care Seriously

For those with more-or-less normal and healthy skin the use of skin care products often contributes relatively little to their short-term appearance, however in rosacea everything that touches your skin matters.

Resolve to take less notice of brands and more about the ingredients their products contain.

Recognize that terms like "sensitive skin" and "natural" are relatively meaningless and usually don't equate with superiority in treatment.

Use Modern Sunscreen

Incidental sun exposure provokes and worsens symptoms in the majority of patients, yet the majority don't use sunscreen on a daily basis.

This is in part due to negative experiences with sunscreens (such as whitening, pasty texture and skin irritation) and the tenacious fallacy that only warm or hot sun can do harm.

Understand that the ultraviolet radiation which worsens rosacea is prevalent year-round, from sunrise to sunset, irrespective of season, cloud coverage or temperature, and that the damage it does is cumulative.

Throw out sunscreens you don't like and replace them with new, superior options.

Resolve to use a sunscreen specific to the needs of rosacea, preferably an antioxidant sunscreen, such as the SPF 20, 30 or 50 together with appropriate skin care and you won't experience irritation or a cosmetically unacceptable finish.

No More Sulfates

The majority of foaming facial cleansers (and shampoos) contain sulfates which function as detergents and surfactants.

The most prevalent is sodium laureth sulphate.

A small number of leave-on products such as moisturizers also contain sulfates.

Their purpose is to remove oils from the skin (and hair) and to make the skin more permeable.

In rosacea they disrupt the skin's barrier function sufficiently that symptoms of burning, stinging, redness, irritation and flushing are more likely to occur.

A study at Bath University found that sodium laureth sulphate in a prescribed moisturizer made symptoms of eczema worse and caused a thinning of the skin.

Spring water and other facial mists can calm the redness of rosacea when used alongside appropriate skin care.

Use an anti-inflammatory and hydrating cleansing product which protects and helps repair the skin's barrier while purifying it such as the Rosacea Anti-Inflammatory Foaming Cleanser or Rosacea Hydrating-Desensitizing Cleansing Emulsion.

Avoiding sulfates in shampoos can also help — see Can Your Shampoo Worsen Your Rosacea?

Spray With Facial Water

They may seem like nonsense, but suitable "facial waters" or "mists" can decrease facial redness and inflammation.

They work by reducing skin temperature and imparting a soothing effect with small amounts of anti-inflammatories such as sulfur.

If you live in an area where the tap water contains harsh chemicals, spraying the skin after cleansing can remove these harmful impurities.

Options include distilled water (if kept uncontaminated), Avene Thermal Spring Water Spray, La Roche-Posay Eau Thermal Spray and the Rosacea De-Sensitizing Mists.

Spray immediately after cleansing, before the application of any other product such as serum, moisturizer or sunscreen, and at any time of the day that your skin feels heated.

Use a facial mist when outdoors and during travel to prevent uncomplicated redness due to rising skin temperature and superficial dehydration from developing into a lengthy episode of flushing.

Repair Your Skin's Barrier

Keeping the skin's surface moist with moisturizer sometimes reduces its tendency to flare-up, but if you can make it less inherently prone to drying out you'll have a better chance of slowly recovering a normal flush response.

Repair your skin's barrier by avoiding ingredients which break it down — these are predominantly the sulfates in facial cleansers mentioned above — and by re-imparting ingredients which intimately bolster its strength — ceramides, cholesterol and phytosphingosines.

Careful cleansing technique is also important in improving skin barrier function — see What is The Best Way To Cleanse?

A healthy diet balanced in Omega 3 and 6 essential fatty acids and avoiding the use of chemical peels, microdermabrasion and other potentially harsh anti-aging measures outside of the recommendation of a dermatologist will also stop you from adversely affecting your skin's ability to keep irritants out.

When your skin's barrier works properly, irritants (from those found in tap water, normally benign products and the environment at large) are much less likely to trigger flushing.

Prevent Dark Marks and Spots

The end-point of redness and inflammation is often a dark spot or patch remaining where the redness has cleared.

Effective treatments for this phenomena (known as hyperpigmentation) are notoriously slow and sometimes make the problem worse.

If you're prone to dark marks or spots make a point of preventing them from happening in the first place.

Keeping inflammation down, using suitable sunscreens and skin care in general, if high in useful antioxidants, can be very effective in preventing this occurrence.

Add Rosacea Anti-Inflammatory Clearing Serum to your evening skin care 2-3 times a week or more. Patients report a progressive lessening of existing dark marks and prevention of new dark spots with the regular use of this product.

Consider Demodex

Demodex mites have been implicated as causative or worsening of rosacea for more than two decades.

Although naturally present in everyone's facial skin, rosacea patients have been found to have higher concentrations of these mites than those without rosacea and treatment of the mites sometimes brings excellent results.

A variety of drugs and ingredients able to be used in skin care products, such as tea tree oil, have been suggested as options, however many of these are strong irritants.

Reformulated in late 2013, the Rosacea Anti-Inflammatory Foaming Cleanser now contains ingredients which have been suggested in the scientific literature as helping control demodex. Many patients have reported dramatic improvement over the original formula.

Armour With Antioxidants

Both topically and orally, antioxidants can help prevent inflammation, burning, stinging and redness, hold back the hands of time and are healthy for you overall.

Look for products containing ubiquinone, tocopherols, caffeine, beta glucan, grape seed, green tea, resveratrol, silymarin, silybin, centella asiatica and various isoflavones and polyphenols.

Drink sugar-free green tea at room temperature or below or add a green tea supplement to water such as Dr. Brandt Antioxidant Water Booster.

Be Patient

The benefits of change take time to surface and accrue.

While positive skin care changes often bring rapid improvement their long-term benefits are less impressive if they're not sustained.

Staying the right course is the most deciding factor in whether or not your skin care resolutions are realised.

Further Information and References

Aqueous Cream Aggravates Eczema — BBC Health News.

Creams Used To Treat Eczema Could Make It Worse — Bath University.

Aqueous Cream for Eczema Questioned — NHS.

Can Your Shampoo Worsen Your Rosacea? — Facebook.

Facial Mists for Rosacea — Facebook.

Green Tea and Red Light — Sommer AP, Zhu D. Photomed Laser Surg. 2009 Dec;27(6):969-71. doi: 10.1089/pho.2009.2547.

Topical Polyphenolic Antioxidants Reduce The Adverse Effects of Intense Pulsed Light Therapy. Freedman BM. Plastic Surgery Associates of Northern Virginia, McLean, Virginia 22102, USA.

Demodex Information and References

Rosacea May Be Caused by Mites — New Scientist.

Bacteria From Mites Might Be Responsible For Rosacea — Huffington Post Healthy Living.

Demodex Infestation Requires Immediate Aggressive Treatment — Primary Care Optometry News.

Potential role of Demodex mites and bacteria in the induction of rosacea — Jarmuda S1, O'Reilly N, Zaba R, Jakubowicz O, Szkaradkiewicz A, Kavanagh K. J Med Microbiol. 2012 Nov;61(Pt 11):1504-10. doi: 10.1099/jmm.0.048090-0. .

Method for treating rosacea using oral or topical ivermectin — William Robert McDaniel.

In vitro and in vivo killing of ocular Demodex by tea tree oil. Br J Ophthalmol. 2005 November; 89(11): 1468—1473.

Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream. Forstinger C, Kittler H, Binder M.. J Am Acad Dermatol. 1999 Nov;41(5 Pt 1):775-7.

Evaluation of the efficacy of oral ivermectin in comparison with ivermectin—metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum — International Journal of Infectious Diseases.

Demodex Treatment Options — Eye World.

New Treatment Directions: Rosacea Research Grants

The National Rosacea Society (NRS) has awarded funding for five new studies as part of its research grants program to increase knowledge and understanding of the potential causes and other key aspects of rosacea.

Enzymes Causing Inflammation

Dr. Anna Di Nardo, associate professor of medicine at the University of California-San Diego, was awarded $25,000 to study the role of mast cells as a possible link between an overabundance of the antimicrobial peptides called cathelicidins in individuals with rosacea and the inflammation that appears on rosacea skin.

Dr. Di Nardo will endeavor to identify inflammation-causing enzymes that are produced by mast cells as well as the influence of neuropeptides on the formation of these key enzymes.

Kallikrein Enzymes

Drs. Ulf Meyer-Hoffert and Thomas Schwartz of the Department of Dermatology, University Clinic Schleswig-Holstein, were awarded $20,000 to study whether and how kallikreins, enzymes that contribute to inflammation in rosacea, can activate cytokines, which might contribute to the disease activity. The investigators will also research inhibitors of this substance that could have the potential to treat the disease.


Drs. Meg Gerstenblith and Daniel Popkin, assistant professors of dermatology at Case Western Reserve University, were awarded $10,000 to study the incidence of rosacea in fraternal and identical twins, recruited at the annual Twins Day festival in Ohio.

The study aims to document potential genetic factors by determining if there is a statistically significant difference in the correlation of rosacea between identical and fraternal twins.

Also see the earlier Study Suggests Hereditary Rosacea Link.

Microbes Specific to Rosacea Skin

Dr. Barbara Summerer, postdoctoral research fellow in dermatology at Johns Hopkins University School of Medicine, was awarded $25,000 to use sophisticated analytical technology to evaluate specific microbes in rosacea patients.

She will further use epifluorescence microscopy to identify possible biofilms — communities of bacteria that adhere to surfaces — that may exist in rosacea patients, as well as the differences in types of bacteria present in subtype 1 (erythematotelangiectatic) rosacea and subtype 2 (papulopustular) rosacea, so that therapy can target these bacteria.

Enhancing Beta-Defensin 2 Production

Dr. Yoshikazu Uchida, associate research dermatologist, and Dr. Peter Elias, professor of dermatology, at the University of California-San Francisco, were awarded $20,000 to study whether and how enhancing the production of human beta-defensin 2 and conversely suppressing the production of cathelicidin antimicrobial peptide, part of the body's innate immune system, may help suppress the excess of inflammation-causing peptides found in rosacea skin.

The NRS is also continuing to fund studies by Dr. Richard Granstein at Cornell University on the potential role of Th17 cells in rosacea and Dr. Edward Wladis at Albany Medical College on identifying cytokines involved in ocular rosacea.

Related Emerging Research and Treatment Topics

Updates on the Pathophysiology and Managment of Rosacea.

Angiogenesis and Mast Cells in Rosacea.

Moisturizers Containing Niacinamide Benefit Rosacea.

Information About Rosacea Is Not Rosacea Treatment Knowledge.

Paraben Preservatives and Sun Damage.

Author: Peter Wilson.

Reviewed: Tuesday, August 9, 2016.

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Restore Serum Pure is now available. Attend is available in 30 and 50 mL sizes. See www.rosacea.net.au

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